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Objective: The purpose of this study is to determine the epidemiological, demographic, clinical and paraclinical indicators of suspected, probable and infected cases of covid-19 referred to Imam Reza Hospital (AS) in 2018-2019. Method(s): This cross-sectional study was conducted using patient information between 2018 and 2019 at Imam Reza Hospital. The method of collecting information in this study was by means of a checklist. Patient information was collected through the files of suspected, probable, and infected patients with Covid-19 who were admitted to Imam Reza Hospital during the implementation of this study in 2018-2019. This checklist included the demographic information of the patients including age, gender, underlying disease, patient symptoms, laboratory findings, hospitalization information, prescription drugs, and the status of the patients at discharge (survivor or deceased). Result(s): A total of 305 patients with an average age of 58.03 +/- 17.40 years were included in the study. 126 patients (41.3%) were positive for covid. The most common clinical symptoms were shortness of breath in 182 patients (59.7%), cough in 178 patients (58.4%) and fever in 177 patients (58%), respectively. The most common underlying diseases were high blood pressure (39.0%) and diabetes (33.4%). The amount of WBC (p=0.018), potassium (P=0.037), urea (P=0.001), CRP (P=0.001), PT (P=0.001) and INR (P=0.001) were significantly higher in deceased patients than in surviving patients. However, the amount of platelets (P=0.047), pH (P=0.001) and HCO3 (P=0.017) in the deceased group was significantly lower than the living group. . In the discussion of hospital data, the duration of intubation (P<0.001), the duration of hospitalization (P=0.036), the duration of hospitalization in the ward (P=0.005) and the duration of hospitalization In ICU (P<0.001), it was significantly higher in patients who died than in those who survived. Conclusion(s): Covid patients usually present with fever, shortness of breath and cough;Among the cases of disease, diabetic and hypertensive patients made up a major part, which shows the susceptibility of this group to the disease. However, only the presence of cardiovascular diseases was associated with higher mortality. Copyright © 2022 Wolters Kluwer Medknow Publications. All rights reserved.
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Background: COVID-19 induced cardiac events are reported by many papers, while psychophysiology of association of the COVID-19 and cardiac attacks are not fully understood yet. Materials and Methods: Here, we compared gene expression levels of heart autopsies of SARS-Cov-2 infected patients with the cardiac organoid model of human myocardial infarction and controlled healthy cardiac organoids to identify differentially expressed genes (DEGs). Gene Ontology (GO) biological processes were enriched in DEGs.
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Background and Objectives: Coronavirus disease 2019 (COVID-19) rapidly spread throughout the world, including Iran. The main measures for preventing the spread of this disease are based on personal hygiene and observance of protocols such as social distancing. It is important for medical and non-medical students to be aware of this disease and how to face it. This study aims to investigate the knowledge, attitude, and practice (KAP) of medical and non-medical students in Mashhad, Iran against regarding COVID-19.
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Background: Coronavirus 2019 (COVID-19) has been at the center of researchers' attention from the beginning of the pandemic due to its global prevalence, and researchers have been conducting many studies and tried a variety of medicinal approaches to combat this pandemic. They aim to find a way to prevent or treat the condition. Every day brings fresh debates and developments, and social media abound with discussions and remarks associated with this global health challenge. Profiteers, on the other hand, promote false information among the public about the treatment of COVID-19 disease despite their limited scientific information and expertise. Several pharmaceutical companies commercialized their herbal-based products during the COVID-19 pandemic. Traditional medicine is mainly rooted in Iranian, Chinese, and Indian traditional medicine, acupuncture, and aromatherapy. A vast amount of information and treatment tactics has been spreading based on the theories in this field. However, in some cases, not only do these have no effect on disease treatment, but they can also have additional negative effects on the person's health and spread viruses even further. Therefore, more scientific studies are needed on the effects of traditional and alternative medicine on the prevention and treatment of COVID-19. Studies performed in this regard have drawbacks, such as a lack of a control group, quality evidence, randomization, and blinding methods, as well as imprecise assessment indicators, and long-term follow-up period. A few of these claims and treatment approaches are discussed in the present study.
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Objective: To examine the relationship between wounding-to-door time and wound healing duration in patients with simple traumatic wounds admitted to Shahid Rajaei Emergency Department (ED) in Tonekabon city during the COVID-19 pandemic. Methods: This was a prospective longitudinal study on patients with simple traumatic wounds referred to ED of Shahid Rajaei Hospital in Tonekabon from April to the end of September 2021 were examined for demographics, trauma to hospital door, and body mass index. Patients were followed for wound healing for a month. Data was analyzed by considering the wound healing time as the primary outcome. Results: There were 142 were males and 45 were females. The mean age of the subjects was 32.24±18.25. The mean wound-to-door time was 4.3±2.7 hours. The maximum and minimum wound-to-door time was 17 hours and 1 hour, respectively. The average wound healing duration was 14.3±3.6 days. A significant positive correlation was found between the wound healing duration and wound-to-door time (r= 0.435, P<0.001). When analyzing subgroups of patients based on the BMI, antibiotic use, smoking status, and some wound locations, there was no significant correlation between wound healing duration and wounding-to-door time (P>0.05). Conclusion: This study revealed that delayed visit of ED for receiving proper wound care would be associated with increased wound healing duration;while this relationship is being modified by smoking status, using antibiotics, and the BMI. © 2023 by SPC (Sami Publishing Company)
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Background: The world is facing the coronavirus 2 pandemic since 2019 (COVID-19 infection) and all countries have challenges in management of patients based on their facilities. Chest computed tomography (CT) scan can be valuable in early detection and estimation of the pulmonary involvement in these patients. Objectives: To evaluate the prognostic value of chest CT imaging features in patients with coronavirus disease 2019 (COVID-19) pneumonia. Patients and Methods: In this cross-sectional study, 201 patients with COVID-19 were enrolled consecutively. The patients’ chest CT scans were analyzed, and the disease severity was rated using two methods: (1) total lung involvement (TLI) in which each lobe is scored from 0 to 4 based on the percentage of involvement;and (2) modified TLI in which each lobe involvement score is multiplied by the number of its segments, and the sum is recorded as the modified TLI. The patients were categorized into four groups depending on their prognosis (patients admitted to hospital wards, patients admitted to intensive care units [ICUs], patients with intubation during hospitalization, and expired patients). The relationship between both scoring methods and the clinical outcomes of patients was examined in the four groups. Results: The receiver operating characteristic (ROC) curve analysis showed no significant difference between the two scoring methods (TLI and modified TLI) in predicting the patients’ prognosis. The average disease severity based on the two scoring methods was significantly different between the four groups. Patients who were intubated during hospitalization and patients who expired had significantly higher scores than patients admitted to the ICUs and hospital wards (P = 0.001). The area under the ROC curve for the prediction of mortality was 0.81 (95% CI: 0.72-0.90;P < 0.001). The TLI score of 18.5 could predict mortality with specificity of > 95%. Conclusion: The TLI scoring system can be used for predicting in-hospital mortality and ICU admission in COVID-19 patients. This scoring method can help us devise a better strategic healthcare plan during the COVID-19 pandemic. © 2021, Author(s).
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Objective: Methanol poisoning is a dangerous life-threatening event, manifested with various symptoms, sometimes very rare ones, that all should be addressed to prevent misdiagnosis of the methanol-poisoned patients. Case Presentation: A 21-year-old young man was brought to the emergency department (ED) with a generalized tonic-clonic (GTC) seizure and he was diagnosed with methanol intoxication. A non-contrast computed tomography (NCCT) of the brain demonstrated findings similar to subarachnoid hemorrhage (SAH). After the brain CT, he had a Glasgow Coma Score (GCS) of 3 and all brainstem reflexes were absent. Neurology consultant agreed with the diagnosis of pseudo-SAH. Brain death was confirmed by a positive apnea test within 24 hours of presentation. Conclusion: It is suggested that compression of dural sinuses due to severe brain edema, reduces the venous drainage and leads to venous engorgement, which appears high attenuated in the background of low-density edematous brain matter. © 2022, Kerman University of Medical Sciences. All rights reserved.
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Introduction: COVID-19 is currently a global pandemic, and coagulation-related mortality has been widely reported in patients suffering from it. Objective: this article aimed to investigate the coagulation profile of COVID-19 patients. Methods: This was a cross-sectional study conducted using a retrospective research design. We recruited patients with COVID-19 admitted to a hospital from June 15th to July 7th, 2020. Upon patients’ entering a blood sample was drawn from each patient for assessing patient’s coagulation profile (PT, PTT, INR, Platelet count);and a chest high-resolution computed tomography (HRCT) scan was performed for each patient. The study patients were divided in to sever group (CO-RADS score 5) and non-sever group (CO-RADS score <5). Results: Thirty-six patients (20 males and 16 females) with a mean age of 54.7±17.5 years were studied. Of them, 11 cases (30.56%) had severe pulmonary involvement. Also, the coagulation profiles were longer in the severe group than non-sever group. As well, the means of platelet count that were 232.440 per microliter in the non-severe group and 289.180 per microliter in the severe and non-sever groups, respectively;but still not statistically significant (p>0.05). The Area under the ROC Curve (AUC) for PT and INR was 0.615 and 0.611, respectively. The AUC for platelet count was 0.680 (95% CI: 0.501 to 0.859) and had an acceptable discriminating power. Conclusions: In this study, we did not find any statistically significant relationship between the results of coagulation tests and the severity of pulmonary involvement according to HRCT scan findings in COVID-19 patients. But further analyses suggest that, except PTT, the other coagulation tests (PT, INR, and platelet count) may discriminate severe COVID-19 patients. © 2021 Tehran University of Medical Sciences.
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Introduction: While our knowledge is limited about COVID-19 immunity, recent cases of reinfection have raised concerns. Case presentation: Here, we report a case of COVID-19 reinfection after three months from recovery in a healthcare worker with negative IgM and IgG at the second infection and positive nasopharyngeal swab Reverse transcription polymerase chain reaction (RT-PCR) test despite being discharged with two negative RT-PCR tests at the first admission. Symptoms at first admission were fever, headache, sore throat, diarrhea, and vomiting and got changed to myalgia and anosmia. Conclusion: The strength of this case report is the long period (three months) between the infection and reinfection while other cases reported in literature were reinfected less than one month after their first infection. © 2021 Tehran University of Medical Sciences.
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Background and Aim: The COVID-19 pandemic is capable of severely affecting the mental health of health care workers, who are at the forefront of this crisis;while the official staff of health organizations is facing the same danger. Therefore, monitoring awareness and other mental health issues to understand the mediating factors and awareness of appropriate interventions is a necessary priority. Therefore, the purpose of this study was to compare the level of knowledge, attitude, and practice of medical and administrative staff in facing the COVID-19 virus. Methods & Materials: This cross-sectional descriptive study was performed on 160 medical and administrative staff of Jahrom hospitals in 2020. Demographic information questionnaire and researcher-made questionnaire of knowledge, attitude and practice of medical personnel about coronavirus (Covid 19) were used to collect information. Data were analyzed using SPSS software version 21 and descriptive and inferential statistical tests.
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Background and Aim: The recent Coronavirus Disease 2019 (COVID-19) outbreak has caused a lot of stress and anxiety in the world. Given that health care workers are at the forefront of fighting against COVID-19, they are the first to be exposed to this disease. Methods & Materials: This is a descriptive cross-sectional study conducted on 402 medical and administrative staff working in hospitals and health centers affiliated to Jahrom University of Medical Sciences in 2020. Data collection tools were a demographic form and the Corona Disease Anxiety Scale (CDAS). Ethical Considerations: This study was approved by the Vice-Chancellor for Research of Jahrom University of Medical Sciences (Code: IR. JUMS. REC.1399.046).